Karen M. Doody, B.Sc. Hons (Dalhousie), Ph.D. (McGill)
Assistant Professor - Environmental Science (Chemistry)
Phone: (709) 639-4800
Email: kdoody@grenfell.mun.ca
Social Media/LinkedIn:
LinkedIn
Research interests/expertise
- Aging; interaction of environment, aging, and disease development
- Environmental toxins and their effect on cancer and autoimmune disease
- Functional foods
- Autoimmune disease (focus on rheumatoid arthritis)
- Cancer
- Translational Medicine
- Protein tyrosine phosphatases
Teaching
- CHEM2400
- BIOC1430
- BIOL3053
- CHEM1200
- CHEM2440
- ENVS3260
Representative scholarly contributions
- Svensson M, Zoccheddu M, Yang S, Nygaard G, Secchi C,
Doody KM, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Zi R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall A-K, Stanford SM, Bottini N. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. (2020)
Science Advances 6(26):eaba4353.
- Manful CF, Vidal NP, Pham TH, Nadeem M, Wheeler E, Hamilton MC,
Doody KM, Thomas RH. Unfiltered beer based marinades reduced exposure to carcinogens and suppressed conjugated fatty acid oxidation in grilled meats. (2020)
Food Control. In press.
- Manful CF, Vidal NP, Pham TH, Nadeem M, Wheeler E, Hamilton MC,
Doody KM, Thomas RH. Rapid determination of heterocyclic amines in ruminant meats using accelerated solvent extraction and ultra-high performance liquid chromatograph-mass spectrometry. (2019)
MethodsX. 6:2686-2697.
- Manful CF, Vidal NP, Pham TH, Nadeem M, Wheeler E, Hamilton MC,
Doody KM, Thomas RH. Dataset on improved nutritional quality and safety of grilled marinated and unmarinated ruminant meat using novel unfiltered beer-based marinades. (2019)
Data Brief. 27:104801.
- Svensson M,
Doody KM, Schmiedel B, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N. Loss-of-function of PTPN2 promotes pathogenic loss of FoxP3+ in RORgt+ Tregs. (2019)
Journal of Clinical Investigation. 129(3):1193-1210. *Highlighted in
Nat Rev Rheumatol. 2019 15:127.
- Pham TH, Vidal NP, Manful CF, Fillier TA, Pumphrey RP,
Doody KM, Thomas RH. Moose and Caribou as Novel Sources of Functional Lipids: Fatty Acid Esters of Hydroxy Fatty Acids, Diglycerides and Monoacetyldiglycerides. (2019)
Molecules. 24(2).
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Doody KM, Bottini N, Firestein GS. (2017) Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes.
Epigenomics. 9(4):479-492.
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Doody KM, Bottini N. (2016) Chondrocyte clocks make cartilage time-sensitive material. J Clin Invest. 126(1):38-9.
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Doody, KM, Stanford, SM, Sacchetti, C, Svensson, MND, Coles, CH, Mitakidis, N, Kiosses, WB, Bartok, B, Fos, C, Cory, E, Sah, R. L, Liu-Bryan, R, Boyle, D. L, Arnett, HA, Mustelin, T, Corr, M, Esko, JD, Tremblay, ML, Firestein, GS, Aricescu, AR, and Bottini, N. (2015) Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.
Science Translational Medicine. 7(288):2.
*Highlighted in
Nat Rev Rheumatol. 2015 11(7):381; awarded the 2016 Lee C. Howley Sr. Prize for Arthritis Scientific Research
- Tiffany A. Fillier, Shrushti Shah, Karen M. Doody, Thu H. Pham, Isabelle Aubry, Michel L. Tremblay, Sukhinder K. Cheema, Jacqueline Blundell, Raymond H. Thomas. Brief exposure of neuronal cells to levels of short chain fatty acids observed in human systemic circulation impair the cell lipid metabolism resulting in associated cell death by apoptosis.
Scientific Reports,
in press
Current research projects and grants
Awards and recognitions
- Lee C. Howley Sr. Prize for Arthritis Scientific Research (Arthritis Foundation) (2016)
- Canadian Institutes of Health Research Postdoctoral Fellowship (2011- 2014)
- Fonds de la Recherche en Santé du Québec Postdoctoral Training Award (2011; declined)
- McGill Integrated Cancer Research Training Program Studentship (2010)
- McGill University Faculty of Medicine Internal Fellowship (2010; declined)
- McGill University Principal’s Graduate Fellowship (2009)
- McGill Faculty of Medicine Internal Fellowship/George G. Harris Fellowship in Cancer Research (2009)
- McGill University Cancer Centre Canderel Conference Travel Award (2009)
- McGill University Cancer Centre Canderel Conference Travel Award (2008)
- McGill University Principal’s Graduate Fellowship (2008)
- McGill University Faculty of Medicine Internal Fellowship (2007; declined)
- McGill University Cancer Consortium Training Grant in Cancer Research (CIHR) renewal (2006)
- McGill University Cancer Consortium Training Grant in Cancer Research (CIHR) (2005)
- Canadian Millennium Scholarship (2005)
- NSERC Undergraduate Student Research Award (2002)
- Second Year Chemistry Award (2002, Grenfell Campus, Memorial University of Newfoundland)
- Florence O’Neill Scholarship (2001, Grenfell Campus, Memorial University of Newfoundland)
- Atlantic Accord Career Development Award (2001, Grenfell Campus, Memorial University of Newfoundland)
- MUN Endowment Fund Scholarship (2000, Grenfell Campus, Memorial University of Newfoundland)
Honours, graduate and post-graduate supervision
Academic Committee Member:
- Beverly Reid (MSc - BEAS), start 2021
- Prasana Oruganti (MSc – Environmental Science), start 2021
- Olaide Ajibola (PhD – Biochemistry), start 2021
- Minh Nguyen (PhD – Environmental Science), start 2020
- Melissa Hamilton (MSc – BEAS), start 2019
- Olwashina Ayinla (MSc – BEAS), start 2019
- Charles Manful (PhD - Environmental Science, Memorial University), start 2017
- Tiffany Fillier (PhD - Environmental Science, Memorial University), start 2016
Thesis Examination Committee Member
- Tiffany Fillier (PhD - Environmental Science, Memorial University), 2019
- Charles Manful (PhD - Environmental Science, Memorial University), 2019
Thesis Reviewer
- Valerie Vinette, Ph.D. Department of Biochemistry, McGill University (2018); “Protein Tyrosine Phosphatases Regulate cancer Bioenergetics and Macrophage Immune Responses”
- Shrushti Shah, MSc, Department of Biochemistry, Memorial University (2019); “Gut Derived Short Chain Fatty Acids Alter Plasma and Hepatic Lipid Metabolism in a Sex-Specific Manner in Long-Evans Rats”